Product Name

Zafirlukast

Name: Zafirlukast - LGM Pharma
SKU: 107753-78-6

CAS Number

107753-78-6

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Product Name:

Zafirlukast

CAS Number:

107753-78-6

Indication:

For the prophylaxis and chronic treatment of asthma.

Mode of Action:

Zafirlukast is a selective and competitive receptor antagonist of leukotriene D_ and E_ (LTD_ and LTE_), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle constriction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.

Pharmacodynamics:

Zafirlukast is a synthetic, selective peptide leukotriene receptor antagonist (LTRA) indicated for the prophylaxis and chronic treatment of asthma. Patients with asthma were found in one study to be 25-100 times more sensitive to the bronchoconstricting activity of inhaled LTD₄ than nonasthmatic subjects. In vitro studies demonstrated that zafirlukast antagonized the contractile activity of three leukotrienes (LTC₄, LTD₄ and LTE₄) in conducting airway smooth muscle from laboratory animals and humans. Zafirlukast prevented intradermal LTD₄-induced increases in cutaneous vascular permeability and inhibited inhaled LTD₄-induced influx of eosinophils into animal lungs.

Metabolism:

Hepatic

Toxicity:

Side effects include rash and upset stomach.

IUPAC:

cyclopentyl N-{3-[(2-methoxy-4-{[(2-methylbenzene)sulfonyl]carbamoyl}phenyl)methyl]-1-methyl-1H-indol-5-yl}carbamate

ATC:

R03DC01

PubChem:

5717

DrugBank:

DB00549 (APRD00377)

Formula:

C₉H₁₃N₃O₃

Molecular Mass:

575.675

SMILES:

COC1=C(CC2=CN(C)C3=C2C=C(NC(=O)OC2CCCC2)C=C3)C=CC(=C1)C(=O)NS(=O)(=O)C1=CC=CC=C1C

AHFS Code:

48:10.2

InChi:

YEEZWCHGZNKEEK-UHFFFAOYSA-N

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Zafirlukast

107753-78-6

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