Product Name

Vorinostat

Name: Vorinostat - LGM Pharma
SKU: 149647-78-9

CAS Number

149647-78-9

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Product Name:

Vorinostat

CAS Number:

149647-78-9

Indication:

For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.

Mode of Action:

Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC5_

Metabolism:

The major pathways of vorinostat metabolism involve glucuronidation and hydrolysis followed by _-oxidation. Human serum levels of two metabolites, O-glucuronide of vorinostat and 4-anilino-4-oxobutanoic acid were measured. Both metabolites are pharmacologically inactive. Compared to vorinostat, the mean steady state serum exposures in humans of the O-glucuronide of vorinostat and 4-anilino-4-oxobutanoic acid were 4-fold and 13-fold higher, respectively. In vitro studies using human liver microsomes indicate negligible biotransformation by cytochromes P450 (CYP).

IUPAC:

N-hydroxy-N'-phenyloctanediamide

ATC:

L01XX38

PubChem:

5311

DrugBank:

DB02546 (EXPT02902)

Formula:

C₁₉H₁₆O₄

Molecular Mass:

264.3202

Synonyms:

MK0683 N-hydroxy-n'-phenyloctanediamide N-hyrdroxy-n'-phenyloctanediamide SAHA SHH Suberanilohydroxamic acid suberoylanilide hydroxamic acid

SMILES:

ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1

InChi:

WAEXFXRVDQXREF-UHFFFAOYSA-N

General Reference:

Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE: Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther. 2006 Aug;5(8):1967-74. Pubmed

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Vorinostat

149647-78-9

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