Product Name

Vonoprazan Fumarate

CAS Number

881681-01-2

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Product Name:
Vonoprazan Fumarate
CAS Number:
881681-01-2
IUPAC:
(E)-but-2-enedioic acid;1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine
ATC:
A02BC08
PubChem:
45375887
DrugBank:
N/a (only available for Vonoprazan
Formula:
C21H20FN3O6S
Molecular Mass:
461.5
InChi:
InChi
Product Description:

Vonoprazan Fumarate is the fumarate salt form of vonoprazan, a pyrrole derivative and reversible potassium-competitive acid blocker (P-CAB), with potential antacid activity. Upon administration, vonoprazan specifically and competitively binds to the gastric hydrogen-potassium ATPase (H+/K+ ATPase) proton pump at or, more likely, near its potassium ion (K+) binding site and sterically inhibits K+ binding. This blocks the activation of the H+/K+ ATPase by K+, inhibits the proton pump and prevents gastric acid secretion, thereby lowering gastric acid levels.

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