Product Name

Vigabatrin

Name: Vigabatrin
SKU: 60643-86-9

CAS Number

60643-86-9

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Product Name:

Vigabatrin

CAS Number:

60643-86-9

Indication:

For use as an adjunctive treatment (with other drugs) in treatment resistant epilepsy, complex partial seizures, secondary generalized seizures, and for monotherapy use in infantile spasms in West syndrome.

Mode of Action:

It is believed that vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase GABA-T) or block the reuptake of GABA into glia and nerve endings. Vigabatrin may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

Pharmacodynamics:

Vigabatrin, is an anticonvulsant chemically unrelated to other anticonvulsants. Vigabatrin inhibits the catabolism of GABA. It is an analog of GABA, but it is not a receptor agonist. Vigabatrin irreversibly inhibits the enzyme GABA transaminase.

Metabolism:

Almost no metabolic transformation. Does not induce the hepatic cytochrome P450 system.

IUPAC:

4-aminohex-5-enoic acid

ATC:

N03AG04

PubChem:

5665

DrugBank:

DB01080 (APRD00282)

Formula:

C₄₆H₅₈N₄O₉

Molecular Mass:

129.157

SMILES:

NC(CCC(O)=O)C=C

AHFS Code:

28:12.9

InChi:

PJDFLNIOAUIZSL-UHFFFAOYSA-N

General Reference:

Gram L, Larsson OM, Johnsen A, Schousboe A: Experimental studies of the influence of vigabatrin on the GABA system. Br J Clin Pharmacol. 1989;27 Suppl 1:13S-17S. Pubmed
Browne TR: Pharmacokinetics of antiepileptic drugs. Neurology. 1998 Nov;51(5 Suppl 4):S2-7. Pubmed
Lindberger M, Luhr O, Johannessen SI, Larsson S, Tomson T: Serum concentrations and effects of gabapentin and vigabatrin: observations from a dose titration study. Ther Drug Monit. 2003 Aug;25(4):457-62. Pubmed
Zwanzger P, Baghai TC, Schuele C, Strohle A, Padberg F, Kathmann N, Schwarz M, Moller HJ, Rupprecht R: Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers. Neuropsychopharmacology. 2001 Nov;25(5):699-703. Pubmed

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Vigabatrin

60643-86-9

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