Product Name

Tucatinib

CAS Number

937263-43-9

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Product Name:
Tucatinib
CAS Number:
937263-43-9
IUPAC:
6-N-(4,4-dimethyl-5H-1,3-oxazol-2-yl)-4-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine
ATC:
L01EH03
PubChem:
51039094
DrugBank:
DB11652
Formula:
C26H24N8O2
Molecular Mass:
480.5
InChi:
InChi
Product Description:

Tucatinib is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. Tucatinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

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