Product Name

Tropicamide

CAS Number

1508-75-4

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Product Name:
Tropicamide
CAS Number:
1508-75-4
Indication:
Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.
Mode of Action:

Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle.

Pharmacodynamics:

Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly.

Toxicity:

Overdose can casue dry mouth, blurred vision, photophobia, hallucinations and rapid/irregular pulse.

IUPAC:
N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
ATC:
S01FA06
PubChem:
5593
DrugBank:
DB00809 (APRD00287)
Formula:
C8H16O2
Molecular Mass:
284.3529
SMILES:
CCN(CC1=CC=NC=C1)C(=O)C(CO)C1=CC=CC=C1
AHFS Code:
52:24.0
InChi:
BGDKAVGWHJFAGW-UHFFFAOYSA-N

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