• # LGM Pharma is a Triamcinolone CAS# 124-94-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Triamcinolone
  • CAS #: 124-94-7
  • Mode of Action:

    The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

  • Pharmacodynamics:

    Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.

  • Metabolism:

    Hepatic.

  • Toxicity:

    LD50=>500mg/kg (in rats)

  • IUPAC: (1R, 2S, 10S, 11S, 13R, 14S, 15S, 17S)-1-fluoro-13, 14, 17-trihydroxy-14-(2-hydroxyacetyl)-2, 15-dimethyltetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadeca-3, 6-dien-5-one
  • ATC: A01AC01 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05 C05AA12
  • PubChem: 31307
  • DrugBank: DB00620 (APRD00422)
  • Formula: C8H8Cl3N3O4S2
  • Molecular Mass: 394.4339
  • Synonyms: Fluoxiprednisolone Fluoxyprednisolone Tiamcinolonum [INN-Latin] Triamcinalone Triamcinolona [INN-Spanish] Triamcinolone acetonide Triamcinolone diacetate Triamcinolone hexacetonide Triamcinolonum [INN]
  • SMILES: C[C@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1C[C@@H](O)[C@]2(O)C(=O)CO
  • AHFS Code: 52:08.08 84:06.00 68:04.00
  • InChl: GFNANZIMVAIWHM-OBYCQNJPSA-N
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LGM Pharma Acquires CDMO

On July 27, 2020, LGM Pharma announced its acquisition of the formulation development and drug product contract manufacturing business of Nexgen Pharma, Inc. As a result, you will notice our new logo and visuals throughout the website. We’re working on updates to reflect the exciting, expanded CDMO capabilities and services we now can offer you.

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