Product Name

Triamcinolone

CAS Number

124-94-7

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Product Name:
Triamcinolone
CAS Number:
124-94-7
Indication:
For the treatment of perennial and seasonal allergic rhinitis.
Mode of Action:

The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

Pharmacodynamics:

Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.

Metabolism:

Hepatic.

Toxicity:

LD50=>500mg/kg (in rats)

IUPAC:
(1R, 2S, 10S, 11S, 13R, 14S, 15S, 17S)-1-fluoro-13, 14, 17-trihydroxy-14-(2-hydroxyacetyl)-2, 15-dimethyltetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadeca-3, 6-dien-5-one
ATC:
A01AC01 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05 C05AA12
PubChem:
31307
DrugBank:
DB00620 (APRD00422)
Formula:
C8H8Cl3N3O4S2
Molecular Mass:
394.4339
Synonyms:
Fluoxiprednisolone Fluoxyprednisolone Tiamcinolonum [INN-Latin] Triamcinalone Triamcinolona [INN-Spanish] Triamcinolone acetonide Triamcinolone diacetate Triamcinolone hexacetonide Triamcinolonum [INN]
SMILES:
C[C@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1C[C@@H](O)[C@]2(O)C(=O)CO
AHFS Code:
52:08.08 84:06.00 68:04.00
InChi:
GFNANZIMVAIWHM-OBYCQNJPSA-N

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