Travoprost free acid is a selective FP prostanoid receptor agonist and is believed to reduce intraocular pressure by increasing the drainage of aqueous humor, which is done primarily through increased uveoscleral outflow and to a lesser extent, trabecular outflow facility.
Travoprost, an isopropyl ester prodrug, is a synthetic prostaglandin F2 alpha analogue that is rapidly hydrolyzed by esterases in the cornea to its biologically active free acid. The travoporst free acid is potent and highly selective for the FP prostanoid receptor.
Travoprost, an isopropyl ester prodrug, is hydrolyzed by esterases in the cornea to its biologically active free acid. Systemically, travoprost free acid is metabolized to inactive metabolites via beta-oxidation of the _(carboxylic acid) chain to give the 1, 2-dinor and 1, 2, 3, 4-tetranor analogs, via oxidation of the 15-hydroxyl moiety, as well as via reduction of the 13, 14 double bond.
Symptoms of overexposure include irritation to the skin, eyes, nose, throat, and respiratory tract.
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6. Electronic Medicines Compendium: Travatan (travoprost) Monograph [Link]
7. Alcon treatment Travatan® receives EU approval for pediatric glaucoma patients: Press Release [Link]
8. Alcon receives FDA approval for first-line use of Travatan Z: Press Release [Link]
9. Travatan Z (travoprost) FDA Label [File]
10. Travoprost Canadian Product Information [File]