Product Name

Tranexamic Acid

Name: Tranexamic Acid - LGM Pharma
SKU: 1197-18-8

CAS Number

1197-18-8

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Product Name:

Tranexamic Acid

CAS Number:

1197-18-8

Indication:

For use in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction. It can also be used for excessive bleeding in menstruation, surgery, or trauma cases.

Mode of Action:

Tranexamic acid competitively inhibits activation of plasminogen (via binding to the kringle domain), thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots, fibrinogen, and other plasma proteins, including the procoagulant factors V and VIII. Tranexamic acid also directly inhibits plasmin activity, but higher doses are required than are needed to reduce plasmin formation.

Pharmacodynamics:

Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin. Tranexamic acid is a competitive inhibitor of plasminogen activation, and at much higher concentrations, a noncompetitive inhibitor of plasmin, i.e., actions similar to aminocaproic acid. Tranexamic acid is about 10 times more potent in vitro than aminocaproic acid. Tranexamic acid binds more strongly than aminocaproic acid to both the strong and weak receptor sites of the plasminogen molecule in a ratio corresponding to the difference in potency between the compounds. Tranexamic acid in a concentration of 1 mg per mL does not aggregate platelets in vitro. In patients with hereditary angioedema, inhibition of the formation and activity of plasmin by tranexamic acid may prevent attacks of angioedema by decreasing plasmin-induced activation of the first complement protein (C1).

Metabolism:

Only a small fraction of the drug is metabolized (less than 5%).

Toxicity:

Oral LD₅₀ in mice is >10 gm/kg. Symptoms of overdosage may be nausea, vomiting, orthostatic symptoms and/or hypotension.

IUPAC:

(1r, 4r)-4-(aminomethyl)cyclohexane-1-carboxylic acid

ATC:

B02AA02

PubChem:

5526

DrugBank:

DB00302 (APRD01270, EXPT00508)

Formula:

C₁₉H₂₂ClN₅O

Molecular Mass:

157.2102

Synonyms:

Tranexamsaeure tranexmic acid Tranhexamic acid Trans AMCHA trans-4-aminomethylcyclohexane-1-carboxylic acid trans-Amcha trans-Tranexamic acid

SMILES:

NC[C@H]1CC[C@@H](CC1)C(O)=O

AHFS Code:

20:28.2

InChi:

GYDJEQRTZSCIOI-LJGSYFOKSA-N

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

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Tranexamic Acid

1197-18-8

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