Product Name

Tolnaftate

Name: Tolnaftate - LGM Pharma
SKU: 2398-96-1

CAS Number

2398-96-1

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Tolnaftate

CAS Number:

2398-96-1

Indication:

Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.

Mode of Action:

Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.

Pharmacodynamics:

Tolnaftate is a synthetic over-the-counter anti-fungal agent.

Toxicity:

Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.

IUPAC:

N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide

ATC:

D01AE18

PubChem:

5510

DrugBank:

DB00525 (APRD01607)

Formula:

C₂₂H₃₁NO

Molecular Mass:

307.409

SMILES:

CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1

AHFS Code:

84:04.08.40

InChi:

FUSNMLFNXJSCDI-UHFFFAOYSA-N

General Reference:

Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. Pubmed
Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Tolnaftate

2398-96-1

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product