Product Name

Tivozanib

CAS Number

475108-18-0

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Product Name:
Tivozanib
CAS Number:
475108-18-0
IUPAC:
1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
ATC:
L01EK03
PubChem:
9911830
DrugBank:
DB11800
Formula:
C22H19ClN4O5
Molecular Mass:
454.9
InChi:
InChi
Product Description:

Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.

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