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Tirofiban

CAS No:
144494-65-5 Categories: , ,
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Product Details:

  • Product Name: Tirofiban
  • CAS #: 144494-65-5
  • Mode of Action:

    Tirofiban is a reversible antagonist of fibrinogen binding to the GP IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation. Platelet aggregation inhibition is reversible following cessation of the infusion of tirofiban.

  • Pharmacodynamics:

    Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. When administered intravenously, tirofiban inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner. When given according to the recommended regimen, >90% inhibition is attained by the end of the 30-minute infusion. Tirofiban has been recently shown in patients with unstable angina to reduce ischemic events at 48 hours following infusion when compared to standard heparin therapy.

  • Metabolism:

    Metabolism appears to be limited.

  • IUPAC: (2S)-2-(butane-1-sulfonamido)-3-{4-[4-(piperidin-4-yl)butoxy]phenyl}propanoic acid
  • ATC: B01AC17
  • PubChem: 60947
  • DrugBank: DB00775 (APRD00304)
  • Formula: C9H8ClN5S
  • Molecular Mass: 440.597
  • SMILES: CCCCS(=O)(=O)N[C@@H](CC1=CC=C(OCCCCC2CCNCC2)C=C1)C(O)=O
  • AHFS Code: 20:12.2
  • InChl: COKMIXFXJJXBQG-NRFANRHFSA-N
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