Product Name

Tetrabenazine

CAS Number

58-46-8

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Product Name:
Tetrabenazine
CAS Number:
58-46-8
Indication:
For the symptomatical treatment of hyperkinetic movement disorder.
Mode of Action:

Tetrabenazine works mainly as a VMAT-inhibitor and as such promotes the early metabolic degradation of the neurotransmitter dopamine. Dopamine is required for fine motor movement, so the inhibition of its transmission can lessen the effects of any hyperkinetic movement.

Metabolism:

CYP2D6 mediated hepatic metabolism.

IUPAC:
9, 10-dimethoxy-3-(2-methylpropyl)-1H, 2H, 3H, 4H, 6H, 7H, 11bH-pyrido[2, 1-a]isoquinolin-2-one
ATC:
N07XX06
PubChem:
6018
DrugBank:
DB04844
Formula:
C7H8N4O2
Molecular Mass:
317.4226
Synonyms:
Tetra benazin Tetrabenazina [inn-spanish] Tetrabenazinum [inn-latin] Tetrabenzaine Tetrabenzine
SMILES:
COC1=C(OC)C=C2C3CC(=O)C(CC(C)C)CN3CCC2=C1
InChi:
MKJIEFSOBYUXJB-UHFFFAOYSA-N
General Reference:
General Reference:

  1. Jankovic J, Beach J: Long-term effects of tetrabenazine in hyperkinetic movement disorders. Neurology. 1997 Feb;48(2):358-62. Pubmed

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