Product Name

Teriparatide

Name: Teriparatide - LGM Pharma
SKU: 52232-67-4

CAS Number

52232-67-4

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Product Name:

Teriparatide

CAS Number:

52232-67-4

Indication:

For the treatment of osteoporosis in men and postmenopausal women who are at high risk for having a fracture. Also used to increase bone mass in men with primary or hypogonadal osteoporosis who are at high risk for fracture.

Mode of Action:

Teriparatide is the portion of human parathyroid hormone (PTH), amino acid sequence 1 through 34 of the complete molecule which contains amino acid sequence 1 to 84. Endogenous PTH is the primary regulator of calcium and phosphate metabolism in bone and kidney. Daily injections of teriparatide stimulate new bone formation leading to increased bone mineral density.

Pharmacodynamics:

Clinical trials indicate that teriparatide increases predominantly trabecular bone in the lumbar spine and femoral neck; it has less significant effects at cortical sites. The combination of teriparatide with antiresorptive agents is not more effective than teriparatide monotherapy. The most common adverse effects associated with teriparatide include injection-site pain, nausea, headaches, leg cramps, and dizziness. After a maximum of two years of teriparatide therapy, the drug should be discontinued and antiresorptive therapy begun to maintain bone mineral density.

Metabolism:

Hepatic

Toxicity:

Effects of overexposure may include headaches, dizziness, dizziness, decreased blood pressured, decreased fetal survival, leg cramps, changes in clinical chemistry including increased in blood levels of calcium, decreased serum phosphorous, and increased urinary calcium and phosphorus.

ATC:

H05AA02

PubChem:

16133850

DrugBank:

DB06285

Formula:

C₁₉H₂₄O₃

Molecular Mass:

4117.715

Synonyms:

hPTH 1-34 PTH1-34 nasal spray synthetic human parathyroid hormone 1-34 ViaDerm hPTH 1-34 ViaDerm-hPTH (1-34)

General Reference:

Stroup J, Kane MP, Abu-Baker AM: Teriparatide in the treatment of osteoporosis. Am J Health Syst Pharm. 2008 Mar 15;65(6):532-9. Pubmed
Close P, Neuprez A, Reginster JY: Developments in the pharmacotherapeutic management of osteoporosis. Expert Opin Pharmacother. 2006 Aug;7(12):1603-15. Pubmed

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Teriparatide

52232-67-4

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