Product Name

Tepotinib

CAS Number

1100598-32-0

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Product Name:
Tepotinib
CAS Number:
1100598-32-0
IUPAC:
3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
ATC:
L01EX21
PubChem:
25171648
DrugBank:
DB15133
Formula:
C29H28N6O2
Molecular Mass:
492.6
InChi:
InChi
Product Description:

Tepotinib is an orally bioavailable inhibitor of met tyrosine kinase with potential antineoplastic activity. Tepotinib selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

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