Product Name

Tenoxicam

CAS Number

59804-37-4

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Product Name:
Tenoxicam
CAS Number:
59804-37-4
Indication:
For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.
Mode of Action:

The antiinflammatory effects of tenoxicam may result from the inhibition of the enzyme cycooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.

Pharmacodynamics:

Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Metabolism:

Tenoxicam is metabolized in the liver to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).

IUPAC:
(3Z)-3-{hydroxy[(pyridin-2-yl)amino]methylidene}-2-methyl-2H, 3H, 4H-1$l, {6}, 5, 2-thieno[2, 3-e][1$l, {6}, 2]thiazine-1, 1, 4-trione
ATC:
M01AC02
PubChem:
5282194
DrugBank:
DB00469 (APRD00011)
Formula:
C26H31Cl2N5O3
Molecular Mass:
337.374
Synonyms:
Tenoxicamum [INN-Latin]
SMILES:
CN1C(=C(/O)NC2=CC=CC=N2)C(=O)C2=C(C=CS2)S1(=O)=O
AHFS Code:
28:08.04.92
InChi:
WZWYJBNHTWCXIM-RAXLEYEMSA-N

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