Product Name

Teniposide

CAS Number

29767-20-2

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Product Name:
Teniposide
CAS Number:
29767-20-2
Indication:
Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia
Mode of Action:

The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.

Pharmacodynamics:

Teniposide is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle, thus preventing cells from entering mitosis. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA: protein cross-links.

IUPAC:
(10R, 11R, 15R, 16S)-16-{[(4aR, 6R, 7R, 8R, 8aS)-7, 8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3, 2-d][1, 3]dioxin-6-yl]oxy}-10-(4-hydroxy-3, 5-dimethoxyphenyl)-4, 6, 13-trioxatetracyclo[7.7.0.0, {3, 7}.0, {11, 15}]hexadeca-1(9), 2, 7-trien-12-one
ATC:
L01CB02
PubChem:
34698
DrugBank:
DB00444 (APRD00649)
Formula:
C19H25N5O4
Molecular Mass:
656.654
Synonyms:
Teniposido [INN-Spanish] Teniposidum [INN-Latin]
SMILES:
COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3COC(O[C@H]3[C@H](O)[C@H]2O)C2=CC=CS2)C2=CC3=C(OCO3)C=C12
AHFS Code:
10:00.0
InChi:
NRUKOCRGYNPUPR-PSZSYXFXSA-N

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