Product Name

Teniposide

Name: Teniposide - LGM Pharma
SKU: 29767-20-2

CAS Number

29767-20-2

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Product Name:

Teniposide

CAS Number:

29767-20-2

Indication:

Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia

Mode of Action:

The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.

Pharmacodynamics:

Teniposide is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle, thus preventing cells from entering mitosis. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA: protein cross-links.

IUPAC:

(10R, 11R, 15R, 16S)-16-{[(4aR, 6R, 7R, 8R, 8aS)-7, 8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3, 2-d][1, 3]dioxin-6-yl]oxy}-10-(4-hydroxy-3, 5-dimethoxyphenyl)-4, 6, 13-trioxatetracyclo[7.7.0.0, {3, 7}.0, {11, 15}]hexadeca-1(9), 2, 7-trien-12-one

ATC:

L01CB02

PubChem:

34698

DrugBank:

DB00444 (APRD00649)

Formula:

C₁₉H₂₅N₅O₄

Molecular Mass:

656.654

Synonyms:

Teniposido [INN-Spanish] Teniposidum [INN-Latin]

SMILES:

COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3COC(O[C@H]3[C@H](O)[C@H]2O)C2=CC=CS2)C2=CC3=C(OCO3)C=C12

AHFS Code:

10:00.0

InChi:

NRUKOCRGYNPUPR-PSZSYXFXSA-N

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Teniposide

29767-20-2

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