Product Name

Simvastatin

Name: Simvastatin - LGM Pharma
SKU: 79902-63-9

CAS Number

79902-63-9

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Product Name:

Simvastatin

CAS Number:

79902-63-9

Indication:

For the treatment of hypercholesterolemia.

Mode of Action:

The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta, delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

Pharmacodynamics:

Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Metabolism:

Hepatic, simvastatin is a substrate for CYP3A4.

IUPAC:

(1S, 3R, 7S, 8S, 8aR)-8-{2-[(2R, 4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3, 7-dimethyl-1, 2, 3, 7, 8, 8a-hexahydronaphthalen-1-yl 2, 2-dimethylbutanoate

ATC:

C10AA01

PubChem:

54454

DrugBank:

DB00641 (APRD00104)

Formula:

C₂₂H₃₀N₂O₅S₂

Molecular Mass:

418.5662

Synonyms:

Simvastatin [Usan:Ban:Inn] Simvastatina [Spanish] Simvastatine [French] Simvastatinum [Latin]

SMILES:

[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC

AHFS Code:

24:06.1

InChi:

RYMZZMVNJRMUDD-HGQWONQESA-N

General Reference:

Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinsonês disease. BMC Med. 2007 Jul 19;5:20. Pubmed

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Simvastatin

79902-63-9

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