• # LGM Pharma is a Simvastatin CAS# 79902-63-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
  • Inquire about this product >>

Product Details:

  • Product Name: Simvastatin
  • CAS #: 79902-63-9
  • Mode of Action:

    The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta, delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

  • Pharmacodynamics:

    Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

  • Metabolism:

    Hepatic, simvastatin is a substrate for CYP3A4.

  • IUPAC: (1S, 3R, 7S, 8S, 8aR)-8-{2-[(2R, 4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3, 7-dimethyl-1, 2, 3, 7, 8, 8a-hexahydronaphthalen-1-yl 2, 2-dimethylbutanoate
  • ATC: C10AA01
  • PubChem: 54454
  • DrugBank: DB00641 (APRD00104)
  • Formula: C22H30N2O5S2
  • Molecular Mass: 418.5662
  • Synonyms: Simvastatin [Usan:Ban:Inn] Simvastatina [Spanish] Simvastatine [French] Simvastatinum [Latin]
  • SMILES: [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC
  • AHFS Code: 24:06.1
  • InChl: RYMZZMVNJRMUDD-HGQWONQESA-N
  • General Reference:

     

    1. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinsonês disease. BMC Med. 2007 Jul 19;5:20. Pubmed

     

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants

 

  • Technical packages as well as access to filed DMF,
    ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any
    submission type based on specific customer requirements
This website uses cookies. By using our site, you agree to our terms of service