• # LGM Pharma is a Simvastatin CAS# 79902-63-9 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Simvastatin
  • CAS #: 79902-63-9
  • Mode of Action:

    The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta, delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

  • Pharmacodynamics:

    Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

  • Metabolism:

    Hepatic, simvastatin is a substrate for CYP3A4.

  • IUPAC: (1S, 3R, 7S, 8S, 8aR)-8-{2-[(2R, 4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3, 7-dimethyl-1, 2, 3, 7, 8, 8a-hexahydronaphthalen-1-yl 2, 2-dimethylbutanoate
  • ATC: C10AA01
  • PubChem: 54454
  • DrugBank: DB00641 (APRD00104)
  • Formula: C22H30N2O5S2
  • Molecular Mass: 418.5662
  • Synonyms: Simvastatin [Usan:Ban:Inn] Simvastatina [Spanish] Simvastatine [French] Simvastatinum [Latin]
  • SMILES: [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC
  • AHFS Code: 24:06.1
  • InChl: RYMZZMVNJRMUDD-HGQWONQESA-N
  • General Reference:

     

    1. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinsonês disease. BMC Med. 2007 Jul 19;5:20. Pubmed

     

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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  • Technical packages as well as access to filed DMF,
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LGM Pharma Acquires CDMO

On July 27, 2020, LGM Pharma announced its acquisition of the formulation development and drug product contract manufacturing business of Nexgen Pharma, Inc. We’re working to update our website to reflect the exciting, expanded CDMO capabilities and services we now can offer you.

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