Product Name

Ropinirole Hydrochloride

Name: Ropinirole Hydrochloride - LGM Pharma
SKU: 91374-20-8

CAS Number

91374-20-8

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Product Name:

Ropinirole Hydrochloride

CAS Number:

91374-20-8

Indication:

For the treatment of the signs and symptoms of idiopathic Parkinson’s disease. Also used for the treatment of restless legs syndrome.

Mode of Action:

Ropinirole binds the dopamine receptors D₃ and D₂. Although the precise mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, it is believed to be related to its ability to stimulate these receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum.

Pharmacodynamics:

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D₂ subfamily of dopamine receptors, binding with higher affinity to D₃ than to D₂ or D₄ receptor subtypes. The relevance of D₃ receptor binding in Parkinson’s disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D₂ -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

Metabolism:

Hepatic. Ropinirole is extensively metabolized to inactive metabolites via N -despropylation and hydroxylation pathways, largely by the P450 isoenzyme CYP1A2. N-despropyl ropinirole is the predominant metabolite found in urine (40%), followed by the carboxylic acid metabolite (10%), and the glucuronide of the hydroxy metabolite (10%).

Toxicity:

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

IUPAC:

2(H)-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1, 3-dihydro-, monohydrochloride

Formula:

C16-H24-N2-O.Cl-H

Molecular Mass:

296.8395

Synonyms:

1,3-Dihydro-4-(2-(dipropylamino)ethyl)-2H-indol-2-one monohydrochloride, 2(H)-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, monohydrochloride, 4-(2-(Dipropylamino)ethyl)-2-indolinone monohydrochloride, ReQuip, ReQuip XL, Ropinirole HCl, Ropinirole hydrochloride, SK&F 101468-A, UNII-D7ZD41RZI9

SMILES:

CCCN(CCC)CCc1cccc2c1CC(=O)N2.Cl

InChi:

1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H

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Ropinirole Hydrochloride

91374-20-8

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