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Product Details:

  • Product Name: Rituximab
  • CAS #: 174722-31-7
  • Mode of Action:

    The Fab regions of rituximab binds to the CD20 antigen on B lymphocytes, while the Fc domain recruits antibodies and complements to mediate cell lysis.

  • Pharmacodynamics:

    Rituximab binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lympohomas. The antibody leads to selective killing of B-cells.

  • Metabolism:

    Most likely removed by opsonization via the reticuloendothelial system when bound to B lymphocytes, or by human antimurine antibody production

  • IUPAC: Immunoglobulin G1, anti-(human CD20 (antigen)(human-mouse monoclonal IDEC-C2B8 gamma1-chain), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer
  • ATC: L01XC02
  • DrugBank: DB00073
  • Formula: C6416-H9874-N1688-O1987-S44
  • Molecular Mass: 143859.7 Da
  • Synonyms: HSDB 7455, IDEC-102, IDEC-C2B8, Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer, Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer. Molecular weight is approximately 144,187 daltons, Mab Thera, MabThera, PF 05280586, PF-05280586, Rituxan, Rituximab, UNII-4F4X42SYQ6
  • AHFS Code: 10:00.0
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