Product Name

Rituximab

CAS Number

174722-31-7

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Product Name:
Rituximab
CAS Number:
174722-31-7
Indication:
For treatment of CD20-positive non-Hodgkins lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis.
Mode of Action:

The Fab regions of rituximab binds to the CD20 antigen on B lymphocytes, while the Fc domain recruits antibodies and complements to mediate cell lysis.

Pharmacodynamics:

Rituximab binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin’s lympohomas. The antibody leads to selective killing of B-cells.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system when bound to B lymphocytes, or by human antimurine antibody production

IUPAC:
Immunoglobulin G1, anti-(human CD20 (antigen)(human-mouse monoclonal IDEC-C2B8 gamma1-chain), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer
ATC:
L01XC02
DrugBank:
DB00073
Formula:
C6416-H9874-N1688-O1987-S44
Molecular Mass:
143859.7 Da
Synonyms:
HSDB 7455, IDEC-102, IDEC-C2B8, Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer, Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer. Molecular weight is approximately 144,187 daltons, Mab Thera, MabThera, PF 05280586, PF-05280586, Rituxan, Rituximab, UNII-4F4X42SYQ6
AHFS Code:
10:00.0

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