Product Name

Reserpine

Name: Reserpine - LGM Pharma
SKU: 50-55-5

CAS Number

50-55-5

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Product Name:

Reserpine

CAS Number:

50-55-5

Indication:

Foe the treatment of hypertension

Mode of Action:

Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.

Pharmacodynamics:

Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.

Toxicity:

Possible human carcinogen. May cause reproductive harm. ORL-RAT LD₅₀ 420 mg/kg; IPR-RAT LD₅₀ 44 mg/kg; IVN-RAT LD₅₀ 15 mg/kg; ORL-MUS LD₅₀ 200 mg/kg; SCU-MUS LD₅₀ 52 mg/kg; IPR-RBT LD₅₀ 7 mg/kg

IUPAC:

methyl (1R, 15S, 17R, 18R, 19S, 20S)-6, 18-dimethoxy-17-[(3, 4, 5-trimethoxyphenyl)carbonyloxy]-3, 13-diazapentacyclo[11.8.0.0, {2, 10}.0, {4, 9}.0, {15, 20}]henicosa-2(10), 4, 6, 8-tetraene-19-carboxylate

ATC:

C02AA02

PubChem:

5770

DrugBank:

DB00206 (APRD00472)

Formula:

C₈H₅F₃N₂OS

Molecular Mass:

608.6787

SMILES:

CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=C4C=CC(OC)=C5)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1

InChi:

QEVHRUUCFGRFIF-MDEJGZGSSA-N

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Reserpine

50-55-5

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