Product Name

Remifentanil

CAS Number

132875-61-7

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Product Name:
Remifentanil
CAS Number:
132875-61-7
Indication:
For use during the induction and maintenance of general anesthesia.
Mode of Action:

Remifentanil is a µ-opioid agonist with rapid onset and peak effect, and short duration of action. The µ-opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone.

Pharmacodynamics:

Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action. The opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. The analgesic effects of remifentanil are rapid in onset and offset. Its effects and side effects are dose dependent and similar to other opioids. Remifentanil in humans has a rapid blood-brain equilibration half-time of 1 ± 1 minutes (mean ± SD) and a rapid onset of action.

Metabolism:

By hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases.

IUPAC:
1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester
ATC:
N01AH06
DrugBank:
DB00899
Formula:
C20-H28-N2-O5
Molecular Mass:
376.4502
Synonyms:
GI 87084X, Remifentanil, Remifentanyl, UNII-P10582JYYK
SMILES:
CCC(=O)N(c1ccccc1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC
AHFS Code:
28:08.1
InChi:
1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3

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