Product Name

Prucalopride

CAS Number

179474-81-8

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Product Name:
Prucalopride
CAS Number:
179474-81-8
Indication:
Investigated for use/treatment in constipation, ileus, and pediatric indications.
Mode of Action:

Prucalopride (PRU) is a selective high affinity 5-HT4 agonist, which are involved in initiating peristalsis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.

Metabolism:

In vitro, human liver metabolism is very slow and only minor amounts of metabolites are found.

IUPAC:
4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2, 3-dihydro-1-benzofuran-7-carboxamide
ATC:
A06AX05
DrugBank:
DB06480
Formula:
C18-H26-Cl-N3-O3
Molecular Mass:
367.8744
Synonyms:
4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide, Prucalopride, UNII-0A09IUW5TP
SMILES:
COCCCN1CCC(CC1)NC(=O)c2cc(c(c3c2OCC3)N)Cl
InChi:
1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)

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