Product Name

Propranolol Hydrochloride

CAS Number


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Product Name:
Propranolol Hydrochloride
CAS Number:
For the prophylaxis of migraine.
Mode of Action:

Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.


Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.




Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).

Molecular Mass:
(+-)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride, 1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride, 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol hydrochloride, 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride, 1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride, 1-Isopropylamino-3-(1-naphthoxy)-propan-2-ol-hydrochloride, 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride, 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride, (+-)-, Acifol, Anaprilin, Anapriline, Angilol, Apsolol, Arcablock, Artensol, Avlocardyl, AY 64043, Beprane, Berkolol, beta Neg, beta-NEG, Beta-Tablinen, Beta-Timelets, Biocard, Blocaryl, Cardinol, Caridolol, CCRIS 1105, Cinlol, Ciplar, Corbeta, d,l-Propranolol hydrochloride, Deralin, Detensol, Dibudinate, DL-Anapriline, DL-Propranolol hydrochloride, Dociton, Dumopranol, Duranol, Duraprox, Efectolol, EINECS 206-268-7, EINECS 222-501-5, Elbrol, Emforal, Farprolol, Frekven, Half-Inderal, HemangeolHemangeol, Hemipralon, Herzbase, Herzul, HSDB 3176, I 2065, ICI 45520, Ikopal, Inderal, Inderal LA, Inderalici, Inderex, Indermigran, Indobloc, Innopran, InnoPran XL, KEMI, Kidoral, Naprilin, Nedis, Nelderal, Noloten, Novopranol, NSC 91523, NSC-91523, Obsidan, Oposim, Panolol, Prandol, Pranix, Prano-Puren, Proberta LA, Procor, Pronovan, Propabloc, Propadex, Propalong, Propayerst, Prophylux, Propra vt ct, Proprahexal, Propral, Propranolol chloride, Propranolol HCl, Propranolol hydrochloride, Propranolol hydrochloride intensol, Propranovitan, Propranur, Propraratiopharm, Prosin, Pur-Bloka, Pylapron, R+C5989educor, Rapynogen, Sagittol, Sawatol, Scandrug, Sinal, Sloprolol, Sudenol, Tensiflex, Tesnol, Tiperal, Tonum, UNII-F8A3652H1V
AHFS Code:
General Reference:
General Reference:

  1. Brunet A, Orr SP, Tremblay J, Robertson K, Nader K, Pitman RK: Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res. 2007 Jun 21;. Pubmed
  2. Ohnishi ST, Sadanaga KK, Katsuoka M, Weidanz WP: Effects of membrane acting-drugs on plasmodium species and sickle cell erythrocytes. Mol Cell Biochem. 1989 Nov 23-Dec 19;91(1-2):159-65. Pubmed
  3. Singh N, Puri SK: Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis. Acta Trop. 2000 Nov 2;77(2):185-93. Pubmed
  4. Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, Haldar K: Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med. 2006 Dec;3(12):e528. Pubmed

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