Product Name

Pramipexole Dihydrochloride

CAS Number

104632-25-9

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Product Name:
Pramipexole Dihydrochloride
CAS Number:
104632-25-9
Indication:
For the treatment of signs and symptoms of idiopathic Parkinson’s disease
Mode of Action:

The precise mechanism of action of Pramipexole as a treatment for Parkinson’s disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum.

Pharmacodynamics:

Pramipexole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson’s disease is unknown. The precise mechanism of action of Pramipexole as a treatment for Parkinson’s disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that Pramipexole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum.

Metabolism:

No metabolites have been identified in plasma or urine.

IUPAC:
2, 6-Benzothiazolediamine, 4, 5, 6, 7-tetrahydro-N6-propyl-, dihydrochloride, (6S)- 2, 6-Benzothiazolediamine, 4, 5, 6, 7-tetrahydro-N6-propyl-, dihydrochloride, (S)-
ATC:
N04BC05
PubChem:
119570
DrugBank:
DB00413 (APRD00156)
Formula:
C10-H17-N3-S.2Cl-H
Molecular Mass:
284.2531
Synonyms:
Mirapex, Mirapex ER, Pramipexole dihydrochloride, Pramipexole HCl, Pramipexole hydrochloride, UNII-4R2HD0M28N
SMILES:
Cl.Cl.c12c(C[C@H](CC2)NCCC)sc(n1)N
AHFS Code:
28:36.20.08
InChi:
1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
General Reference:
General Reference:

Mierau J, Schneider FJ, Ensinger HA, Chio CL, Lajiness ME, Huff RM: Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36. [PubMed:7664822

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