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CAS Number


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Product Name:
CAS Number:
Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins and uncomplicated reticular veins in the lower extremity.
Mode of Action:

When administered, polidocanol locally damages blood vessel endothelium. Following the endothelial damage, platelets aggregate at the site and attach to the venous wall eventually resulting in a dense network of platelets, cellular debris, and fibrin that occludes the vessel. Eventually the vessel is replaced by connective fibrous tissue.


Polidocanol has a concentration and volume dependent damaging effect on the blood vessel endothelium.


Metabolism was not measured.


Most adverse reactions are related to the intravenous administration such as local irritation, pain, and hematoma. Extravasation can also be an issue.

3, 6, 9, 12, 15, 18, 21, 24, 27-Nonaoxanonatriacontan-1-ol Polyethylene glycol monododecyl ether (average polymer, n = 9)
Molecular Mass:
Asclera, EINECS 221-284-4, Laureth-9, Nonaethylene glycol monododecyl ether, Polidocanol, Polyethylene glycol monododecyl ether (average polymer, n = 9; nonaethylene glycol monododecyl ether)
General Reference:
General Reference:

Peterson JD, Goldman MP, Weiss RA, Duffy DM, Fabi SG, Weiss MA, Guiha I: Treatment of reticular and telangiectatic leg veins: double-blind, prospective comparative trial of polidocanol and hypertonic saline. Dermatol Surg. 2012 Aug;38(8):1322-30. doi: 10.1111/j.1524-4725.2012.02422.x. Epub 2012 May 23. [PubMed:22620717]
Weiss RA, Voigts R, Howell DJ: Absence of concentration congruity in six compounded polidocanol samples obtained for leg sclerotherapy. Dermatol Surg. 2011 Jun;37(6):812-5. doi: 10.1111/j.1524-4725.2011.01906..x. [PubMed:21605244]
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