Product Name

Phenytoin

Name: Phenytoin - LGM Pharma
SKU: 57-41-0

CAS Number

57-41-0

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Phenytoin

CAS Number:

57-41-0

Indication:

For the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery.

Mode of Action:

Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.

Pharmacodynamics:

Phenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures. Phenytoin acts to dampen the unwanted, runaway brain activity seen in seizure by reducing electrical conductance among brain cells. It lacks the sedation effects associated with phenobarbital. There are some indications that phenytoin has other effects, including anxiety control and mood stabilization, although it has never been approved for those purposes by the FDA. Phenytoin is primarily metabolized by CYP2C9.

Metabolism:

Primarily hepatic

Toxicity:

Oral, mouse: LD₅₀ = 150 mg/kg; Oral, rat: LD₅₀ = 1635 mg/kg. Symptoms of overdose include coma, difficulty in pronouncing words correctly, involuntary eye movement, lack of muscle coordination, low blood pressure, nausea, sluggishness, slurred speech, tremors, and vomiting.

IUPAC:

5, 5-diphenylimidazolidine-2, 4-dione

ATC:

N03AB02 N03AB04 N03AB05

DrugBank:

DB00252 (APRD00241)

Formula:

C₁₀H₁₆Br₂N₂O₂

Molecular Mass:

252.268

Synonyms:

5,5-diphenylhydantoin 5,5-Dwufenylohydantoina Difenilhidantoina [Spanish] Dihydantoin Diphenylan Sodium Diphenylhydantoin Diphenylhydantoine [French] Diphenylhydatanoin Fenitoina [INN-Spanish] Phenytoin Sodium Phenytoine Phenytoine [INN-French] Phenytoinum [INN-Latin]

SMILES:

O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC=CC=C1

AHFS Code:

28:12.1

InChi:

CXOFVDLJLONNDW-UHFFFAOYSA-N

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Phenytoin

57-41-0

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product