Product Name

Phenylbutazone

CAS Number

50-33-9

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Product Name:
Phenylbutazone
CAS Number:
50-33-9
Indication:
For the treatment of backache and ankylosing spondylitis
Mode of Action:

Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Pharmacodynamics:

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Toxicity:

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

IUPAC:
4-butyl-1, 2-diphenylpyrazolidine-3, 5-dione
ATC:
M01AA01 M02AA01
PubChem:
4781
DrugBank:
DB00812 (APRD00409, DB08343)
Formula:
C19H20N2O3S
Molecular Mass:
308.3743
SMILES:
CCCCC1C(=O)N(N(C1=O)C1=CC=CC=C1)C1=CC=CC=C1
AHFS Code:
28:08.04.92
InChi:
VYMDGNCVAMGZFE-UHFFFAOYSA-N

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