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Pertuzumab

  • # LGM Pharma is a Pertuzumab CAS# 380610-27-5 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Pertuzumab
  • CAS #: 380610-27-5
  • Mode of Action:

    Pertuzumab is a humanized monoclonal antibody designed to bind to the HER2 receptor and inhibit the ability of HER2 to interact with other HER family members (HER1, HER2, HER3, and HER4) on the surface of cancer cells. The HER signaling pathway plays a role in the formation and growth of numerous cancers, and previous clinical trials of pertuzumab in a single agent setting had suggested clinical activity - including stable disease - in heavily pretreated patients with advanced ovarian and breast cancers.

  • Toxicity:

    The most common adverse reactions (> 30%) with PERJETA in combination with trastuzumab and docetaxel were diarrhea, alopecia, neutropenia, nausea, fatigue, rash, and peripheral neuropathy.

  • IUPAC: Immunoglobulin G1, anti-(human v (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer
  • ATC: L01XC13
  • DrugBank: DB06366
  • Synonyms: 2C4, HSDB 8141, Omnitarg, Omnitarg, 2C4, Perjeta, Pertuzumab, rhuMAb 2C4, UNII-K16AIQ8CTM
  • AHFS Code: 10:00
  • General Reference:

     

    1. Protein sequence Link
    2. FDA label

     

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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