Product Name

Perampanel

CAS Number

380917-97-5

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Product Name:
Perampanel
CAS Number:
380917-97-5
Indication:
Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.
Mode of Action:

The exact mechanism of action of perampanel in seizures is not yet determined, but it is known that perampanel decreases neuronal excitation by non-competitive ihibition of the AMPA receptor.

Pharmacodynamics:

Perampanel is involved in inhibiting neuronal excitation in the central nervous system leading to such effects as decreased pyschomotor performance.

Metabolism:

Perampanel is highly metabolized by CYP3A4 and/or CYP3A5 primary oxidation and by sequential glucuronidation.

Toxicity:

The FDA label includes an important warning of serious or life-threatening behavioral and psychiatric adverse reactions including aggression, hostility, irritability, anger, and homicidal thoughts in patients taking perampanel.

ATC:
N03AX22
DrugBank:
DB08883
Synonyms:
E-2007
General Reference:
General Reference:

  1. Hanada T, Hashizume Y, Tokuhara N, Takenaka O, Kohmura N, Ogasawara A, Hatakeyama S, Ohgoh M, Ueno M, Nishizawa Y: Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. 2011 Jul;52(7):1331-40. doi: 10.1111/j.1528-1167.2011.03109._. Epub 2011 Jun 2. Pubmed
  2. FDA label.

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