Product Name

Pentoxifylline

Name: Pentoxifylline - LGM Pharma
SKU: 4905d00b1192

CAS Number

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Pentoxifylline

CAS Number:

Indication:

For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.

Mode of Action:

Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. It is also a non selective adenosine receptor antagonist.

Pharmacodynamics:

Pentoxifylline, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.

Toxicity:

LD₅₀=1385 mg/kg(orally in mice)

IUPAC:

3, 7-dimethyl-1-(5-oxohexyl)-2, 3, 6, 7-tetrahydro-1H-purine-2, 6-dione

ATC:

C04AD03

PubChem:

4740

DrugBank:

DB00806 (APRD00121)

Formula:

C₁₈H₁₆O₃

Molecular Mass:

278.307

Synonyms:

EHT0201

SMILES:

CN1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C

AHFS Code:

20:24.0

InChi:

BYPFEZZEUUWMEJ-UHFFFAOYSA-N

General Reference:

: European Pentoxifylline Multi-Infarct Dementia Study. Eur Neurol. 1996;36(5):315-21. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Pentoxifylline

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product