Product Name

Pentoxifylline

Name: Pentoxifylline - LGM Pharma
SKU: 4905d00b1192

CAS Number

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Product Name:

Pentoxifylline

CAS Number:

Indication:

For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.

Mode of Action:

Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. It is also a non selective adenosine receptor antagonist.

Pharmacodynamics:

Pentoxifylline, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.

Toxicity:

LD₅₀=1385 mg/kg(orally in mice)

IUPAC:

3, 7-dimethyl-1-(5-oxohexyl)-2, 3, 6, 7-tetrahydro-1H-purine-2, 6-dione

ATC:

C04AD03

PubChem:

4740

DrugBank:

DB00806 (APRD00121)

Formula:

C₁₈H₁₆O₃

Molecular Mass:

278.307

Synonyms:

EHT0201

SMILES:

CN1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C

AHFS Code:

20:24.0

InChi:

BYPFEZZEUUWMEJ-UHFFFAOYSA-N

General Reference:

: European Pentoxifylline Multi-Infarct Dementia Study. Eur Neurol. 1996;36(5):315-21. Pubmed

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Pentoxifylline

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