Product Name

Paliperidone Palmitate

Name: Paliperidone Palmitate - LGM Pharma
SKU: 199739-10-1

CAS Number

199739-10-1

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Product Name:

Paliperidone Palmitate

CAS Number:

199739-10-1

Indication:

For the treatment of schizophrenia.

Mode of Action:

Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia, is unknown, but it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.

Pharmacodynamics:

Paliperidone is an atypical antipsychotic developed by Janssen Pharmaceutica. Chemically, paliperidone is primary active metabolite of the older antipsychotic risperidone (paliperidone is 9-hydroxyrisperidone). While its specific mechanism of action is unknown, it is believed paliperidone and risperidone act via similar, if not the same, pathways.

Metabolism:

Although in vitro studies suggested a role for CYP2D6 and CYP3A4 in the metabolism of paliperidone, in vivo results indicate that these isozymes play a limited role in the overall elimination of paliperidone. Four primary metabolic pathways have been identified in vivo, none of which could be shown to account for more than 10% of the dose: dealkylation, hydroxylation, dehydrogenation, and benzisoxazole scission. Paliperidone does not undergo extensive metabolism and a significant portion of its metabolism occurs in the kidneys.

Toxicity:

The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis.

IUPAC:

Hexadecanoic acid, 3-(2-(4-(6-fluoro-1, 2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6, 7, 8, 9-tetrahydro-2-methyl-4-oxo-4H-pyrido(1, 2-a)pyrimidin-9-yl ester

ATC:

N05AX13

PubChem:

115237

DrugBank:

DB01267

Formula:

C39-H57-F-N4-O4

Molecular Mass:

664.9013

Synonyms:

(9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidin-9-yl hexadecanoate, Hexadecanoic acid, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl ester, Invega Sustenna, Invega Trinza, Paliperidone Palmitate, RO 92670, RO92670, Trinza, UNII-R8P8USM8FR, Xeplion

SMILES:

CCCCCCCCCCCCCCCC(=O)OC1CCCn2c1nc(c(c2=O)CCN3CCC(CC3)c4c5ccc(cc5on4)F)C

AHFS Code:

28:16.08.04

InChi:

1S/C39H57FN4O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18-36(45)47-34-17-16-24-44-38(34)41-29(2)32(39(44)46)23-27-43-25-21-30(22-26-43)37-33-20-19-31(40)28-35(33)48-42-37/h19-20,28,30,34H,3-18,21-27H2,1-2H3

General Reference:

Jones MP, Nicholl D, Trakas K: Efficacy and tolerability of paliperidone ER and other oral atypical antipsychotics in schizophrenia. Int J Clin Pharmacol Ther. 2010 Jun;48(6):383-99. Pubmed
Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. Pubmed

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Paliperidone Palmitate

199739-10-1

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