Product Name

Oxazepam

Name: Oxazepam - LGM Pharma
SKU: 604-75-1

CAS Number

604-75-1

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Oxazepam

CAS Number:

604-75-1

Indication:

For the treatment of anxiety disorders and alcohol withdrawal.

Mode of Action:

Similar to other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA-A receptors through a cooperative mechanism of action. GABA receptors are ionotropic chloride-linked channel receptors that produce inhibitory postsynaptic potentials. When activated by GABA, the GABA receptor/chloride ionophore complex undergoes a conformational change that allows the passage of chloride ions through the channel. Benzodiazepines are believed to exert their effect by increasing the effect of GABA at its receptor. Benzodiazepine binding increases chloride conductance in the presence of GABA by increasing the frequency at which the channel opens. In contrast, barbiturates increase chloride conductance in the presence of GABA by prolonging the time in which the channel remains open. There are _8 subtypes of the GABA receptor subunits. The __ subunit of the ______ receptor complex is thought to mediate anxiolytic effects while the __ subunit of the ______ receptor complex is thought to mediate sedative, anticonvulsant and anterograde amnesia effects.

Pharmacodynamics:

Oxazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.

Metabolism:

No active metabolites. Metabolized via conjugation prior to elimination.

Toxicity:

Symptoms of overdose include confusion, drowsiness, and lethargy.

IUPAC:

7-chloro-3-hydroxy-5-phenyl-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one

ATC:

N05BA04

PubChem:

4616

DrugBank:

DB00842 (APRD01152)

Formula:

C₁₉H₂₀N₂O₃

Molecular Mass:

286.713

Synonyms:

Oxazipam Oxozepam

SMILES:

OC1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2

AHFS Code:

28:24.1

InChi:

ADIMAYPTOBDMTL-UHFFFAOYSA-N

General Reference:

Peppers MP: Benzodiazepines for alcohol withdrawal in the elderly and in patients with liver disease. Pharmacotherapy. 1996 Jan-Feb;16(1):49-57. Pubmed
Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. Pubmed
Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. Pubmed
Christensen P, Lolk A, Gram LF, Kragh-Sorensen P: Benzodiazepine-induced sedation and cortisol suppression. A placebo-controlled comparison of oxazepam and nitrazepam in healthy male volunteers. Psychopharmacology (Berl). 1992;106(4):511-6. Pubmed
Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine] Arch Fr Pediatr. 1977 Jan;34(1):74-89. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Oxazepam

604-75-1

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product