Product Name

Oxaprozin

CAS Number

21256-18-8

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Product Name:
Oxaprozin
CAS Number:
21256-18-8
Indication:
Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
Mode of Action:

Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin is a non-selective NSAID, with a cell assay system showing lower COX-2 selectivity implying higher COX-1 selectivity.

Pharmacodynamics:

Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.

Metabolism:

Hepatic. Ester and ether glucuronide are the major conjugated metabolites of oxaprozin, and do not have significant pharmacologic activity.

Toxicity:

Oral, mouse: LD50 = 1210 mg/kg; Oral, rabbit: LD50 = 172 mg/kg; Oral, rat: LD50 = 4470 mg/kg

IUPAC:
3-(diphenyl-1, 3-oxazol-2-yl)propanoic acid
ATC:
M01AE12
PubChem:
4614
DrugBank:
DB00991 (APRD00030)
Formula:
C22H31NO3
Molecular Mass:
293.3166
Synonyms:
Oxaprozina [INN-Spanish] Oxaprozine [INN-French] Oxaprozinum [INN-Latin]
SMILES:
OC(=O)CCC1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1
AHFS Code:
28:08.04.92
InChi:
OFPXSFXSNFPTHF-UHFFFAOYSA-N
General Reference:
General Reference:

  1. Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90. Pubmed

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