Product Name

Orphenadrine

Name: Orphenadrine - LGM Pharma
SKU: 83-98-7

CAS Number

83-98-7

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Orphenadrine

CAS Number:

83-98-7

Indication:

Indicated for the treatment of Parkinson's disease.

Mode of Action:

Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.

Pharmacodynamics:

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Metabolism:

Biotransformation occurs mainly in the liver. Pharmacologically active metabolites are N-demethyl orphenadrine and N, N-didemethyl orphenadrine.

Toxicity:

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

IUPAC:

dimethyl({2-[(2-methylphenyl)(phenyl)methoxy]ethyl})amine

ATC:

M03BC01 N04AB02

PubChem:

4601

DrugBank:

DB01173 (APRD00097)

Formula:

C₁₅H₁₁ClN₂O₂

Molecular Mass:

269.3813

Synonyms:

Mephenamine O-Methyldiphenhydramine Orphenadine Orphenadrin Orphenadrine Citrate Orphenate Orphenedrine

SMILES:

CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1C

AHFS Code:

12:20.0

InChi:

QVYRGXJJSLMXQH-UHFFFAOYSA-N

General Reference:

Ji D, Sui ZY, Ma YY, Luo F, Cui CL, Han JS: NMDA receptor in nucleus accumbens is implicated in morphine withdrawal in rats. Neurochem Res. 2004 Nov;29(11):2113-20. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Orphenadrine

83-98-7

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product