Product Name

Ondansetron

Name: Ondansetron Base - LGM Pharma
SKU: 99614-02-05

CAS Number

99614-02-05

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Product Name:

Ondansetron

CAS Number:

99614-02-05

Indication:

For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, postoperation, and radiation. Also used for the treatment of postoperative nausea and vomiting.

Mode of Action:

Ondansetron is a selective serotonin 5-HT_ receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT_ receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT_ receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

Pharmacodynamics:

Ondansetron is a highly specific and selective serotonin 5-HT₃ receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serontonin 5-HT₃ receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema. The temporal relationship between the emetogenic action of emetogenic drugs and the release of serotonin, as well as the efficacy of antiemetic agents suggest that chemotherapeutic agents release serotonin from the enterochromaffin cells of the small intestine by causing degenerative changes in the GI tract. The serotonin then stimulates the vagal and splanchnic nerve receptors that project to the medullary vomiting center, as well as the 5-HT₃ receptors in the area postrema, thus initiating the vomiting reflex, causing nausea and vomiting.

Metabolism:

Hepatic

Toxicity:

Low blood pressure and fainting, sudden blindness, severe constipation

IUPAC:

9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2, 3, 4, 9-tetrahydro-1H-carbazol-4-one

ATC:

A04AA01

PubChem:

4595

DrugBank:

DB00904 (APRD00481)

Formula:

C₂₉H₄₄O₁₂

Molecular Mass:

293.363

SMILES:

CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2

AHFS Code:

56:22.2

InChi:

FELGMEQIXOGIFQ-UHFFFAOYSA-N

General Reference:

Ramsook C, Sahagun-Carreon I, Kozinetz CA, Moro-Sutherland D: A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis. Ann Emerg Med. 2002 Apr;39(4):397-403. Pubmed
Yilmaz HL, Yildizdas RD, Sertdemir Y: Clinical trial: oral ondansetron for reducing vomiting secondary to acute gastroenteritis in childrenãa double-blind randomized study. Aliment Pharmacol Ther. 2010 Jan;31(1):82-91. Epub . Pubmed
Gregory RE, Ettinger DS: 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs. 1998 Feb;55(2):173-89. Pubmed
Gan TJ: Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS Drugs. 2005;19(3):225-38. Pubmed

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Ondansetron

99614-02-05

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