Product Name

Omalizumab

Name: Omalizumab - LGM Pharma
SKU: 242138-07-4

CAS Number

242138-07-4

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

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Product Name:

Omalizumab

CAS Number:

242138-07-4

Indication:

For treatment of asthma caused by allergies

Mode of Action:

Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.

Pharmacodynamics:

Xolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system.

ATC:

R03DX05

DrugBank:

DB00043

Formula:

C6450H9916N1714O2023S38

Molecular Mass:

145058.2 Da

AHFS Code:

49:32.0

General Reference:

Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR, Gould HJ: Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol. 2003 Apr;33(4):1030-40. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

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Omalizumab

242138-07-4

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