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Omalizumab

  • # LGM Pharma is a Omalizumab CAS# 242138-07-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Omalizumab
  • CAS #: 242138-07-4
  • Mode of Action:

    Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.

  • Pharmacodynamics:

    Xolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.

  • Metabolism:

    Most likely removed by opsonization via the reticuloendothelial system.

  • ATC: R03DX05
  • DrugBank: DB00043
  • Formula: C6450H9916N1714O2023S38
  • Molecular Mass: 145058.2 Da
  • AHFS Code: 49:32.0
  • General Reference:

     

    1. Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR, Gould HJ: Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol. 2003 Apr;33(4):1030-40. Pubmed

     

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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