Product Name

Norgestimate

CAS Number

35189-28-7

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Product Name:
Norgestimate
CAS Number:
35189-28-7
Indication:
For the prevention of pregnancy
Mode of Action:

Norgestimate binds to androgen and progestogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Norgestimate will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Pharmacodynamics:

Norgestimate is used as a female contraceptive. Norgestimate is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Norgestimate tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.

Metabolism:

GI tract/Hepatic

IUPAC:
(1S, 2R, 5E, 10R, 11S, 14R, 15S)-15-ethyl-14-ethynyl-5-(hydroxyimino)tetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadec-6-en-14-yl acetate
ATC:
G03AA11
PubChem:
6540478
DrugBank:
DB00957 (APRD00569)
Formula:
C17H20N4S
Molecular Mass:
369.4971
Synonyms:
Dexnorgestrel Acetime Norgestimato [INN-Spanish] Norgestimatum [INN-Latin]
SMILES:
CC[C@]12CC[C@H]3[C@@H](CCC4=CC(CC[C@H]34)=NO)[C@@H]1CC[C@@]2(OC(C)=O)C#C
InChi:
KIQQMECNKUGGKA-NMYWJIRASA-N

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