Product Name

Nimesulide

CAS Number

51803-78-2

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Product Name:
Nimesulide
CAS Number:
51803-78-2
Indication:
For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Mode of Action:

The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Pharmacodynamics:

Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.

Metabolism:

Hepatic. Extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active).

Toxicity:

Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg

IUPAC:
N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
ATC:
M01AX17 M02AA26
DrugBank:
DB04743
Formula:
C18H20N2O6
Molecular Mass:
308.31
SMILES:
CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O
InChi:
HYWYRSMBCFDLJT-UHFFFAOYSA-N

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Questions? Call our customer API support number 1-(800)-881-8210. 

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