Product Name

Niclosamide

CAS Number

50-65-7

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Product Name:
Niclosamide
CAS Number:
50-65-7
Indication:
For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
Mode of Action:

Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA.

Pharmacodynamics:

Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism.

Toxicity:

Infrequent, mild, and transitory adverse events include nausea, vomiting, diarrhea, and abdominal discomfort.

IUPAC:
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
ATC:
P02DA01
DrugBank:
DB06803
Formula:
C13H12N2O5S
Molecular Mass:
327.12
SMILES:
OC1=C(C=C(Cl)C=C1)C(=O)NC1=C(Cl)C=C(C=C1)[N+]([O-])=O
InChi:
RJMUSRYZPJIFPJ-UHFFFAOYSA-N

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