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Muromonab CD3

CAS No:
140608-64-6 Categories: , , ,
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Product Details:

  • Product Name: Muromonab CD3
  • CAS #: 140608-64-6
  • Mode of Action:

    Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.

  • Pharmacodynamics:

    Used in organ transplant prophylaxis, Muromonab or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients.

  • Metabolism:

    Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production

  • ATC: L04AA02
  • DrugBank: DB00075
  • Formula: C6460H9946N1720O2043S56
  • Molecular Mass: 146189.7 Da
  • Synonyms: Anti-CD3,
  • AHFS Code: 32:00.0
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