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Montelukast

CAS No:
158966-92-8 Categories: , ,
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Product Details:

  • Product Name: Montelukast
  • CAS #: 158966-92-8
  • Mode of Action:

    Montelukast selectively antagonizes leukotriene D_ (LTD_) at the cysteinyl leukotriene receptor, CysLT_, in the human airway. Montelukast inhibits the actions of LTD_ at the CysLT_ receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

  • Pharmacodynamics:

    Montelukast, like zafirlukast, is a leukotriene receptor antagonist used as an alternative to anti-inflammatory medications in the management and chronic treatment of asthma and exercise-induced bronchospasm (EIB). Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4 and is, therefore, not expected to affect the hepatic clearance of drugs metabolized by these enzymes.

  • Metabolism:

    Hepatic

  • Toxicity:

    Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.

  • IUPAC: 2-[1-({[(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl}methyl)cyclopropyl]acetic acid
  • ATC: R03DC03
  • PubChem: 60951
  • DrugBank: DB00471 (APRD00434)
  • Formula: C19H27N5O4
  • Molecular Mass: 586.183
  • SMILES: OC(=O)CC1(CC1)CS[C@H](CCC1=CC=CC=C1C(O)(C)C)C1=CC=CC(C=CC2=NC3=C(C=CC(Cl)=C3)C=C2)=C1
  • AHFS Code: 48:10.2
  • InChl: UCHDWCPVSPXUMX-TZIWLTJVSA-N
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