Product Name

Milrinone

CAS Number

78415-72-2

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Product Name:
Milrinone
CAS Number:
78415-72-2
Indication:
Indicated for the treatment of congestive heart failure.
Mode of Action:

Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.

Pharmacodynamics:

Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.

Metabolism:

There are five metabolites but the O-glucuronide represents the major pathway of biotransformation.

Toxicity:

LD50 = 0.3 mg/L in rats

IUPAC:
6-methyl-2-oxo-5-(pyridin-4-yl)-1, 2-dihydropyridine-3-carbonitrile
ATC:
C01CE02
PubChem:
4197
DrugBank:
DB00235 (APRD00010)
Formula:
C22H28N4O6
Molecular Mass:
211.2194
Synonyms:
Milrinone Lactate
SMILES:
CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1
AHFS Code:
24:04.1
InChi:
PZRHRDRVRGEVNW-UHFFFAOYSA-N

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