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Miconazole

  • # LGM Pharma is a Miconazole CAS# 22916-47-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Miconazole
  • CAS #: 22916-47-8
  • Mode of Action:

    Miconazole interacts with 14-_ demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

  • Pharmacodynamics:

    Miconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Miconazole was approved by the FDA in 1974. Miconazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

  • Toxicity:

    Oral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.

  • IUPAC: 1-[2-(2, 4-dichlorophenyl)-2-[(2, 4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
  • ATC: A01AB09 A07AC01 D01AC02 G01AF04 J02AB01 S02AA13
  • PubChem: 4189
  • DrugBank: DB01110 (APRD01115)
  • Formula: C18H14Cl4N2O
  • Molecular Mass: 416.129
  • Synonyms: MCZ
  • SMILES: ClC1=CC(Cl)=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1
  • AHFS Code: 84:04.08.08
  • InChl: InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2
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