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Product Details:

  • Product Name: Metoprolol
  • CAS #: 51384-51-1
  • Mode of Action:

    Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.

  • Pharmacodynamics:

    Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).

  • Metabolism:

    Primarily hepatic

  • Toxicity:

    LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)

  • IUPAC: 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
  • DrugBank: DB00264
  • Formula: C15-H25-N-O3
  • Molecular Mass: 267.3665
  • Synonyms: (RS)-Metoprolol, Beatrolol, Betaloc, CCRIS 4198, CGP 2175, Corvitol, dl-Metoprolol, EINECS 257-166-4, HSDB 6531, Loresor, Meijoprolol, Metohexal, Metoprolol, Metoprololum, Metoprololum [INN-Latin], Metrol, Minax, Neobloc, Preblok, Presolol, Selokeen, Seroken, Spesicor, Toprol, UNII-GEB06NHM23
  • SMILES: N(CC(COc1ccc(cc1)CCOC)O)C(C)C
  • InChl: 1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
  • General Reference:

     

    1. : Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet. 1999 Jun 12;353(9169):2001-7. Pubmed
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