Product Name

Methocarbamol

Name: Methocarbamol - LGM Pharma
SKU: 0532-03-06

CAS Number

0532-03-06

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Product Name:

Methocarbamol

CAS Number:

0532-03-06

Indication:

For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.

Mode of Action:

The mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.

Pharmacodynamics:

Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect.

Metabolism:

Hepatic.

Toxicity:

Symptoms of overdose include blurred vision, coma, drowsiness, low blood pressure, nausea, and seizures.

IUPAC:

2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate

ATC:

M03BA03

PubChem:

4107

DrugBank:

DB00423 (APRD01102)

Formula:

C₂₀H₃₀O₂

Molecular Mass:

241.2405

SMILES:

COC1=CC=CC=C1OCC(O)COC(N)=O

AHFS Code:

12:20.0

InChi:

GNXFOGHNGIVQEH-UHFFFAOYSA-N

General Reference:

Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, Wright G: Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol. 1990;39(2):193-4. Pubmed

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Methocarbamol

0532-03-06

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