Product Name

Metaxalone

Name: Metaxalone - LGM Pharma
SKU: 1665-48-1

CAS Number

1665-48-1

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Metaxalone

CAS Number:

1665-48-1

Indication:

For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.

Mode of Action:

The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.

Pharmacodynamics:

Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.

Metabolism:

Probably hepatic.

Toxicity:

LD₅₀=775mg/kg (Rat, oral); LD₅₀=1690 mg/kg (Mouse, oral). When determining the LD₅₀ in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD₅₀ could be determined as the higher doses produced an emetic action in 15 to 30 minutes.

IUPAC:

5-(3, 5-dimethylphenoxymethyl)-1, 3-oxazolidin-2-one

PubChem:

15459

DrugBank:

DB00660 (APRD00514)

Formula:

C₁₀H₁₃NO₄

Molecular Mass:

221.2524

Synonyms:

Metassalone [Dcit] Metaxalon Metaxalona [INN-Spanish] Metaxalonum [INN-Latin] Metaxalonum [Latin] Metazalone Metazolone Methaxalonum Methoxolone

SMILES:

CC1=CC(OCC2CNC(=O)O2)=CC(C)=C1

InChi:

IMWZZHHPURKASS-UHFFFAOYSA-N

General Reference:

See S, Ginzburg R: Choosing a skeletal muscle relaxant. Am Fam Physician. 2008 Aug 1;78(3):365-70. Pubmed
Elenbaas JK: Centrally acting oral skeletal muscle relaxants. Am J Hosp Pharm. 1980 Oct;37(10):1313-23. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Metaxalone

1665-48-1

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product