Product Name

Metaxalone

CAS Number

1665-48-1

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Product Name:
Metaxalone
CAS Number:
1665-48-1
Indication:
For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.
Mode of Action:

The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.

Pharmacodynamics:

Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.

Metabolism:

Probably hepatic.

Toxicity:

LD50=775mg/kg (Rat, oral); LD50=1690 mg/kg (Mouse, oral). When determining the LD50 in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes.

IUPAC:
5-(3, 5-dimethylphenoxymethyl)-1, 3-oxazolidin-2-one
PubChem:
15459
DrugBank:
DB00660 (APRD00514)
Formula:
C10H13NO4
Molecular Mass:
221.2524
Synonyms:
Metassalone [Dcit] Metaxalon Metaxalona [INN-Spanish] Metaxalonum [INN-Latin] Metaxalonum [Latin] Metazalone Metazolone Methaxalonum Methoxolone
SMILES:
CC1=CC(OCC2CNC(=O)O2)=CC(C)=C1
InChi:
IMWZZHHPURKASS-UHFFFAOYSA-N
General Reference:
General Reference:

  1. See S, Ginzburg R: Choosing a skeletal muscle relaxant. Am Fam Physician. 2008 Aug 1;78(3):365-70. Pubmed
  2. Elenbaas JK: Centrally acting oral skeletal muscle relaxants. Am J Hosp Pharm. 1980 Oct;37(10):1313-23. Pubmed

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