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Meclizine

CAS No:
569-65-3 Category:
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Product Details:

  • Product Name: Meclizine
  • CAS #: 569-65-3
  • Mode of Action:

    Along with its actions as an antagonist at H_-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.

  • Pharmacodynamics:

    Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.

  • Metabolism:

    Hepatic

  • Toxicity:

    Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).

  • IUPAC: 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
  • ATC: R06AE05
  • PubChem: 4034
  • DrugBank: DB00737 (APRD00354)
  • Formula: C20H22N2S
  • Molecular Mass: 390.948
  • SMILES: CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1
  • AHFS Code: 56:22.1
  • InChl: OCJYIGYOJCODJL-UHFFFAOYSA-N
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