Product Name

Lorazepam

Name: Lorazepam - LGM Pharma
SKU: 846-49-1

CAS Number

846-49-1

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Product Name:

Lorazepam

CAS Number:

846-49-1

Indication:

For the management of anxiety disorders, and for treatment of status epilepticus.

Mode of Action:

Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron.

Pharmacodynamics:

Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.

Metabolism:

Hepatic

Toxicity:

Somnolence, confusion, and coma, LD₅₀=3178mg/kg (orally in mice).

IUPAC:

7-chloro-5-(2-chlorophenyl)-3-hydroxy-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one

ATC:

N05BA06

PubChem:

3958

DrugBank:

DB00186 (APRD00116)

Formula:

C₂₉H₃₈N₄O₁₀

Molecular Mass:

321.158

Synonyms:

(+/-)-Lorazepam O-Chlorooxazepam O-Chloroxazepam

SMILES:

OC1N=C(C2=CC=CC=C2Cl)C2=C(NC1=O)C=CC(Cl)=C2

AHFS Code:

28:24.1

InChi:

DIWRORZWFLOCLC-UHFFFAOYSA-N

General Reference:

Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (authorês transl)] Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. Pubmed
Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. Pubmed
Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. Pubmed
Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. Pubmed
Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. Pubmed

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Lorazepam

846-49-1

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