Product Name

Lorazepam

CAS Number

846-49-1

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Product Name:
Lorazepam
CAS Number:
846-49-1
Indication:
For the management of anxiety disorders, and for treatment of status epilepticus.
Mode of Action:

Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron.

Pharmacodynamics:

Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.

Metabolism:

Hepatic

Toxicity:

Somnolence, confusion, and coma, LD50=3178mg/kg (orally in mice).

IUPAC:
7-chloro-5-(2-chlorophenyl)-3-hydroxy-2, 3-dihydro-1H-1, 4-benzodiazepin-2-one
ATC:
N05BA06
PubChem:
3958
DrugBank:
DB00186 (APRD00116)
Formula:
C29H38N4O10
Molecular Mass:
321.158
Synonyms:
(+/-)-Lorazepam O-Chlorooxazepam O-Chloroxazepam
SMILES:
OC1N=C(C2=CC=CC=C2Cl)C2=C(NC1=O)C=CC(Cl)=C2
AHFS Code:
28:24.1
InChi:
DIWRORZWFLOCLC-UHFFFAOYSA-N
General Reference:
General Reference:

  1. Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (authorês transl)] Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. Pubmed
  2. Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. Pubmed
  3. Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. Pubmed
  4. Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. Pubmed
  5. Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. Pubmed

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