Product Name

Levoleucovorin Calcium

CAS Number

80433-71-2

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:
Levoleucovorin Calcium
CAS Number:
80433-71-2
Indication:
to diminish the toxicity and counteract the action of folic acid antagonists such as methotrexate in cytotoxic therapy and overdose in adults and children
Toxicity:

Mouse(iv): LD50 732 mg/kg

IUPAC:
calcium;(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
PubChem:
135500522
Formula:
C20H21CaN7O7
Molecular Mass:
511.112837 g/mol
Synonyms:
5 Formyltetrahydrofolate, 5 Formyltetrahydropteroylglutamate, 5-Formyltetrahydrofolate, 5-Formyltetrahydropteroylglutamate, Acid, Folinic, Calcium Folinate, Calcium Leucovorin, Citrovorum Factor, Factor, Citrovorum, Folinate, Calcium, Folinic Acid, Folinic Acid SF, Folinic Acid-SF, Leucovorin, Leucovorin, (D)-Isomer, Leucovorin, (DL)-Isomer, Leucovorin, (R)-Isomer, Leucovorin, Calcium, Leucovorin, Calcium (1:1) Salt, Leucovorin, Calcium (1:1) Salt, (DL)-Isomer, Leucovorin, Calcium (1:1) Salt, Pentahydrate, Leucovorin, Monosodium Salt, Leukovorin, Leukovorum, Monosodium Salt Leucovorin, N(5)-Formyltetrahydrofolate, Wellcovorin
SMILES:
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]
InChi:
InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12-,13-;/m0./s1
Product Description:

Levoleucovorin Calcium is a levo isoform of leucovorin calcium with antineoplastic activity. Levoleucovorin is an active metabolite of folic acid, which does not require metabolism by dihydrofolate reductase. This agent counteracts the toxic effects of other folic acid derivative agents, rescuing the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug’s metabolite to its target enzyme, thus prolonging drug activity.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210. 

Ask us about this product

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants
  • Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any submission type based on specific customer requirements

Find an API Product

Search
Generic filters